Small Airway Absorption and Microdosimetry of Inhaled Corticosteroid Particles after Deposition
نویسندگان
چکیده
منابع مشابه
Size of Inhaled Corticosteroid and Small Airway Inflammation in Asthma
99 On the basis of knowledge that asthma is a chronic inflamma-tory disorder of the airways, evidence-based practice guidelines have recommended anti-inflammatory controller therapy to improve asthma outcomes during the past 3 decades. Recently published guidelines have emphasized the role of anti-inflammatory maintenance therapy to prevent chronic persistence and troublesome exacerbations of a...
متن کاملDeposition and clearance of inhaled particles.
Theoretical models of respiratory tract deposition of inhaled particles are compared to experimental studies of deposition patterns in humans and animals, as governed principally by particle size, density, respiratory rate and flow parameters. Various models of inhaled particle deposition make use of approximations of the respiratory tract to predict fractional deposition caused by fundamental ...
متن کاملDeposition of Inhaled Particles in the Lungs
Inhaled medication is the first-line treatment of diseases such as asthma or chronic obstructive pulmonary disease. Its effectiveness is related to the amount of drug deposited beyond the oropharyngeal region, the place where the deposit occurs and its distribution (uniform or not). It is also important to consider the size of the inhaled particles, the breathing conditions, the geometry of the...
متن کاملDeposition of inhaled particles in the lungs.
Inhaled medication is the first-line treatment of diseases such as asthma or chronic obstructive pulmonary disease. Its effectiveness is related to the amount of drug deposited beyond the oropharyngeal region, the place where the deposit occurs and its distribution (uniform or not). It is also important to consider the size of the inhaled particles, the breathing conditions, the geometry of the...
متن کاملFactors influencing the deposition of inhaled particles.
Because the initial deposition pattern of inhaled particles of various toxic agents determines their future clearance and insult to tissue, respiratory tract deposition is important in assessing the potential toxicity of inhaled aerosols. Factors influencing the deposition of inhaled particles can be classified into three main areas: (1) the physics of aerosols, (2) the anatomy of the respirato...
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ژورنال
عنوان ژورنال: Pharmaceutical Research
سال: 2017
ISSN: 0724-8741,1573-904X
DOI: 10.1007/s11095-017-2210-7